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Posts Tagged ‘biology’

3D Printing Graduates to Printing Human Tissue!!

Tuesday, May 29th, 2018

The first thought of 3D printing is construction material, blueprints, and even some innovative ideas about printing physical material. This thought of 3D printing has been re-invented over the past 3-5 years and has been making waves across the world.  Major printer manufacturers are lining up to reinvent this type of printer and technologically advance its features. The possibilities of 3D printing are endless with the future unfolding. Even though still at its infancy state, there are some companies and technology enthusiasts which have decided to take 3D printing to another level. This next level could change the way how medical practice is done, save lives, and give humanity a much-needed foothold on life.

The new level of 3D printing which we speak of is a 3D printer which can print body tissue.  Yes, you did read correctly, a 3D printer which can print human body tissue. Impossible, you say? Well that is what many said when the first person discovered the world is not flat or that space is impossible, but it is now a reality.  There so many discoveries and unthought of inventions that lay within human beings. The untapped potential within society is only the beginning of our potential. 3D printing is now tailoring the impossible to now being possible.  3D printing of human tissue will essentially change the makeup of the medical industry and how tissue replacement is done.

This 3D printer was originally designed to build therapeutic biomaterials. With recent enhancements, this printer has printed test materials.  The test materials that this printer is capable of printing is so complex and precise in its product that they closely resemble human tissue. One of the most remarkable features of human tissue is its complexity. Complexity in the design, function, and capabilities is what makes human tissue so hard to replicate. For this reason, when it comes to replacing tissue, the only replacement in previous years has been getting tissue from a donor.  If this printer can pass the test of its products being able to not only have the complexity of human organs, but then to function the same, then this printer will essentially change the way how we currently go about replacing tissue.

Many people that need transplants and other body tissues could get immediate treatment and not have to wait on a donor list, someone to qualify, or run the risk of losing their lives. Revolutionizing the health industry is something that is often slow and coming, but when there is innovation to bring about that change, it is always worth the effort.  Replacing human tissue depending on the need for that part could be at the cost of someone else’s life or even if not costing the other person their life, putting them at risk due to surgery.  Eliminating this need is not only a desire, but also a requirement that this 3D printer can possibly solve.

Ali Khademhosseini, which is a professor at UCLA is leading the charge with this technology and is certain of its capabilities.  According to Professor Khademhosseini, its about changing the approach which allows them the ability to build complex biocompatible structures from various materials. The brains behind the 3D printer is two components which allows it to create the complexity needed to achieve what other 3D printers cannot currently do.  The first component is a custom-built microfluidic chip. This chip is the brains behind the flow of fluid into micrometer-sized channels.  Each of the inlets that Is printed with different material. Within the microfluidic chip is over a million mirrors which move independently. This gives the function of being able to mix, pump, sort, or control biochemical environments.  All of the aforementioned components work together.  This process of functions cohesively working is called “automated stereolithographic bioprinting”.

 

Automated Stereolithographic bioprinting uses the mirrors in the microfluidic chip to redirect light on to the surface that is being printed.  Due to the intensity of the light, it allows the printer to trace the object that is being printed.  The intensity of the light cause molecular bonds that are formed called hydrogel bioinks which are used in tissue engineering. The molecular changes cause the organ to firm and extends. This is the same type of function which is done in human tissues whether it be lungs, liver, heart, kidney, or muscle.

 

The team at UCLA first started this project creating pyramids then rapidly realized that the potential of this product.  So far, the team has built tumors and muscle tissue. These tissues that were 3D printed also come with their network of blood vessels. Excluding the muscles, the tumors are slatted to be used as biological models which in studies to treat cancer.  Needless to say the potentials for this printer is not only needed, but also shows the direction that technology is going in the future.   It Gurus Of Atlanta is the premier Microsoft partner of choice that will follow up to ensure that any innovations and changes in technology is captured and brought to focus for our audience.

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Artificial Embryos – Gateway To Human Cloning!

Saturday, March 24th, 2018

As the world gears and braces for the inevitable impacts of Artificial Intelligence, Robots, and full automation, many are left with questions. Some people are worried about jobs as they diminish, and automation increases, there are concerns over where the job market will be headed. It’s amazing to grasp that just a few years ago, the computer, the internet, and the whole concept of technology took a foothold in society. Right now, because of the uprising, many jobs have literally disappeared and other once never thought of jobs now exist. The truth is that life and society change every day. The key that all of us need to understand is that for us to not get left behind, then we must learn, adapt, and change. We are either the ones changing the world, or the world will change us. Many fear that the combination of machine learning and artificial intelligence will spawn a new race of robots which will have their own version of right or wrong. However, the one discovery which has managed to go below the radars is very significant, even more so than AI, is the creation of “Artificial Embryos”.

In case you took a breather and did a recheck of what was said in the last paragraph, you are correct in what you read. An embryo is what cells combine to form and what houses the beginnings of life. We all as mammals start out as embryos after fertilization takes place. The embryo develops the cells which in turn have their own DNA sequence that multiply and divide, then manifest into different parts of the body which determine sex, hair color, arm length, bone structure, and all the characteristics of an offspring.  All of this comes from an embryo.  There are constant studies and new developments as scientists do research on this mysterious, yet crucial part of life.  Yue Shao, whom has a background in Biomedical Engineering and Mechanical Engineering made an astounding discovery during this research and experimentation that has profound possibilities in the world of biology.

Yue Shao has been experimenting with stem cells and scaffolds of soft gel to determine replication of neural tissue. By pure accident and experimentation, Dr. Shao stumbled upon more than was bargained for.  The cells in the gel began to change and rapidly arrange at rate that was astounding. They began to form a lopsided circle.  In comparison, the embryo that Dr. Shao created was very much aligned with the same type of embryo which was in the uterine wall and starting to form the amniotic sac. The human embryo and the embryo that Dr. Shao was working on was identical.  The possibilities of this developing into a human required the Dr. to reach out to other groups to determine what to do with the embryo.

After more research and development, the team determined that the embryo would not fully develop into a human being because it did not have the cells required to form major organs such as a brain, heart, or placenta.  However, even though the “embryoids” lacked the required cells, because of their indistinguishable likeness to that of human embryos, the team has been destroying the embryos in formaldehyde and detergent. The ethical repercussions of the embryo going full term and what would come out of that development is too much of a risk to bring to light currently.  This does not stop Pandora’s box which has already been opened to push other researchers to now want to create a full human embryo. One particular group in Cambridge, U.K., has since developed a very convincing 6 day old mouse embryo and are now pushing the limits to create a human embryo.

Many may ask and wonder if the goal is to replicate human beings or to develop another race. For now researchers are limiting the research to focus on combining different stem cells to create bits of lung, intestine, and brain cells to make tissue.  By the discovery of Dr. Shao, the race is now in place and the torch has been lit for the group to first develop an actual human embryo.  A research group in Rockefeller University out of New York has joined the race and they are dubbing the new technology to be called “synthetic embryology”. 

 

This breakthrough is biologist have been searching for as previous attempts at creating an embryo resulted in embryos only growing up to a week before diminishing.  The new discovery was growing at such a rapid rate that superseded previous attempts that the team with Dr. Shao had to terminate the process because they had no concept of what the embryo would have developed into.   Up until now much of the events that take place during the development of a human from the embryo stage is still a mystery.  Human cloning and creating replicas of a person are all on the table with this epic discovery. Now the possibilities of unlocking the process beyond the failed attempts are currently on the table due to Dr. Shao.

To take this to another level, the possibilities of creating real skin, human organs and human traits would take an android to another level of advancements towards being more like human beings. With the advancements of Artificial Intelligence, Robotics, and now stem research, the possibilities are now endless. Where we will go with these advancements as we open doors, we will have to see the direction that we allow the technology to lead us.  Infusing technology and biology is a conception which has been brought to light many years ago from the introduction of the computer.  With the influx of data being readily available and the communication expansions that have connected us all allows for these developments to surge and expand. The more questions that we ask is the more technology responds with answers and advancements. IT GURUS OF ATLANTA prides ourselves as leaders in the technology space and will keep providing updates in this arena.

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